Doramapimod__p38 MAP kinase inhibitor Kaempferol
Product Name
Doramapimod
Description
p38 MAP kinase inhibitor
Purity
>99% (HPLC)
CAS No.
285983-48-4
Molecular Formula
C31H37N5O3
Molecular Weight
527.7
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
White solid
SMILES
C2=CC(=C1C=CC=CC1=C2NC(NC3=CC(=NN3C4=CC=C(C=C4)C)C(C)(C)C)=O)OCCN5CCOCC5
InChI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChIKey
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Doramapimod (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-442)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121476
Alternative Names
JNK Inhibitor XVII, BIRB796, 1-5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl-3-4-(2-morpholin-4-ylethoxy)naphthalen-1-ylurea
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
156422
Scientific Background
Doramapimod is a highly potent and selective inhibitor of p38α MAPK. It specifically blocks TNFα release.
References
1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272.
p38 MAP kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.