Dorsomorphin__AMPK kinase inhibitor TRV130 (hydrochloride)
Product Name
Dorsomorphin
Description
AMPK kinase inhibitor
Purity
>98% (HPLC)
CAS No.
866405-64-3
Molecular Formula
C24H25N5O
Molecular Weight
399.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (4 mg/ml, warm)
Source
Synthetic
Appearance
Yellow solid
SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
InChI
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChIKey
XHBVYDAKJHETMP-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Cite This Product
Dorsomorphin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-443)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121497
Alternative Names
AMPK Inhibitor, Compound C, 6-4-(2-Piperidin-1-ylethoxy)phenyl-3-pyridin-4-ylpyrazolo1,5-apyrimidine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
11524144
Scientific Background
Dorsomorphin is a potent and selective and reversible inhibitor of AMP-kinase, doing so in an ATP-competitive manner. It is also a selective inhibitor of Bone morphogenetic protein (BMP) signaling.
References
1. Vucicevic L., et al. (2011) Autophagy 7(1): 40–50.
2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.
AMPK kinase inhibitor
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.