Dovitinib__FGFR3 inhibitor A939572
Product Name
Dovitinib
Description
FGFR3 inhibitor
Purity
>98%
CAS No.
405169-16-6
Molecular Formula
C21H21FN6O
Molecular Weight
392.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
Crystalline solid
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N
InChI
InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-
InChIKey
KCOYQXZDFIIGCY-ZZEZOPTASA-N
Safety Phrases
Classification:
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Target Organ Systemic Toxicity (single exposure), Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
Cite This Product
Dovitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-500)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121595
Alternative Names
4-amino-5-fluoro-3-6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl-2(1H)-quinolinone
Research Areas
Cell Signaling
PubChem ID
9886808
Scientific Background
Dovitinib is a potent growth factor receptor kinase inhibitor with effects against FLT-3, c-KIT, VEGFR, PDGFRß and CSF-1R.
References
1. Konecny G.E., et al. (2013) Mol. Cancer Ther. 12(5): 632–642.
FGFR3 inhibitor
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Target Organ Systemic Toxicity (single exposure), Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.