Doxorubicin Hydrochloride__Autophagy inducer GSK2330672
Product Name
Doxorubicin Hydrochloride
Description
Autophagy inducer
Purity
>98% (TLC); NMR (Conforms)
CAS No.
25316-40-9
Molecular Formula
C27H29NO11•HCl
Molecular Weight
580
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in water (50 mM).
Source
Synthetic
Appearance
Red solid
SMILES
email protected2(OC1OC(C(O)C(N)C1)C)CC@@(O)(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)C(=O)CO.H+.Cl-
InChI
InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3
InChIKey
MWWSFMDVAYGXBV-RUELKSSGSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Cite This Product
Doxorubicin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-390)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121623
Alternative Names
Adriamycin
Research Areas
Cancer, Autophagy
PubChem ID
443939
Scientific Background
Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
References
1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55.
2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.