E-4031__Herg channel blocker AT9283
Product Name
E-4031
Description
Herg channel blocker
Purity
>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms
CAS No.
113558-89-7
Molecular Formula
C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
Molecular Weight
510.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml)
Source
Synthetic
Appearance
White solid
SMILES
CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.O.O.Cl.Cl
InChI
InChI=1S/C21H27N3O3S.2ClH.2H2O/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;;;/h3-9,18,23H,10-15H2,1-2H3;2*1H;2*1H2
InChIKey
AJNFQUKPBCGJKX-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Cite This Product
E-4031 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-317)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19122272
Alternative Names
N-4-1-2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinylcarbonylphenylmethanesulfonamide dihydrochloride, dihydrate
Research Areas
Ion Channels, Neuroscience
PubChem ID
5312116
Scientific Background
E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
References
1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68.
2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.
3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.
4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.
5. Miyake K., et al. (1990) J Med Chem. 33: 903.
Herg channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.
3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.
4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.
5. Miyake K., et al. (1990) J Med Chem. 33: 903.