Ebselen

Ebselen__Protein Kinase C inhibitor (±)-BI-D

Product Name Ebselen
Description

Protein Kinase C inhibitor

Purity >99%
CAS No. 60940-34-3
Molecular Formula C13H9NOSe
Molecular Weight 274.18
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO and 100% ethanol
Source Synthetic
Appearance Off-white Solid
SMILES C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3Se2
InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChIKey DYEFUKCXAQOFHX-UHFFFAOYSA-N
Safety Phrases Classification: Harmful: May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
23/25-33-50/53
Hazard Phrases:
H301-H331-H373-H410
Precautionary Phrases:
P261-P273-P301 + P310-P311-P501
Cite This Product Ebselen (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-204)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19122305/

Alternative Names 2-Phenyl-1,2-benzoselenazol-3(2H)-one
Research Areas Cancer, Apoptosis
PubChem ID 3194
Scientific Background Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
References 1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169.
2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619.
3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17.
4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.