Epothilone B__Microtubule stabilizer BPTES
Product Name
Epothilone B
Description
Microtubule stabilizer
Purity
>98%
CAS No.
152044-54-7
Molecular Formula
C27H41NO6S
Molecular Weight
507.68
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 10 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
Cemail protected1CCCC@@2(C@@H(O2)Cemail protected(OC(=O)CC@@H(C(C(=O)C@@H(email protected1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
InChI
InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)
InChIKey
QXRSDHAAWVKZLJ-PVYNADRNSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Epothilone B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-238)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19123155
Alternative Names
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl-4,17-dioxabicyclo14.1.0heptadecane-5,9-dione, Patupilone
Research Areas
Cancer, Apoptosis
PubChem ID
448013
Scientific Background
Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3).
References
1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins.
2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772.
3. Balog D.M., et al. (1996) Angew Chem. 108: 2976.
Microtubule stabilizer
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772.
3. Balog D.M., et al. (1996) Angew Chem. 108: 2976.