b-AP15 (NSC-687852)__DUB inhibitor Volasertib
Product Name
b-AP15 (NSC-687852)
Description
DUB inhibitor
Purity
>98%
CAS No.
1009817-63-3
Molecular Formula
C22H17N3O6
Molecular Weight
419.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 35 mg/ml DMSO
Source
Synthetic
Appearance
Pale Yellow Solid
SMILES
C=CC(=O)N1C/C(=CC2=CC=C(C=C2)N+(=O)O-)/C(=O)/C(=C/C3=CC=C(C=C3)N+(=O)O-)/C1
InChI
InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChIKey
GFARQYQBWJLZMW-JYFOCSDGSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
b-AP15 (NSC-687852) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-339)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116074/
Alternative Names
(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone
Research Areas
Cancer, Apoptosis
PubChem ID
5351435
Scientific Background
Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
References
1. D’Arcy P., et al. (2011) Nature Medicine 17: 1636.
DUB inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes