EX-527

EX-527__SIRT1 inhibitor AZD-8055

Product Name	EX-527
Description	SIRT1 inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	49843-98-3
Molecular Formula	C13H13ClN2O
Molecular Weight	248.7

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 18 mg/ml DMSO or 10 mg/ml Ethanol
Source	Synthetic
Appearance	Light Yellow Solid
SMILES	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
InChI	InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
InChIKey	FUZYTVDVLBBXDL-UHFFFAOYSA-N
Safety Phrases	Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H301 – Toxic if swallowed H319 – Causes serious eye irritation Precautionary Statements: P301 + P310 – If swallowed: Immediately call a POSION Center P305 + P351 + P338: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product	EX-527 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-353)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19123978

Alternative Names	6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole-1-carboxamide (racemic)
Research Areas	Cell Signaling, Epigenetics
PubChem ID	5113032
Scientific Background	Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.
References	1. Solomon J.M., et al., (2006) Mol. Cell. Biol. 26: 28. 2. Anderson J.L., et al., (2011) Mol.Cell 43: 834.