FK506

FK506__FKBP inhibitor S1RA (hydrochloride)

Product Name	FK506
Description	FKBP inhibitor
Purity	>98%
CAS No.	109581-93-3
Molecular Formula	C44H69NO12·H2O
Molecular Weight	804.02

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in ethanol, and to 100 mM in DMSO
Source	Synthetic
Appearance	White Solid
SMILES	CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
InChI	InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)4
InChIKey	QJJXYPPXXYFBGM-LFZNUXCKSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301 Precautionary Phrases: P301 + P310
Cite This Product	FK506 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-214)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124513

Alternative Names	3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)prolinate, Tacrolimus, Fujimycin
Research Areas	Cancer, Apoptosis
PubChem ID	445643
Scientific Background	FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3).
References	1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766. 2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530 3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815