FTY720 Hydrochloride__S1P receptor ligand Tozadenant
Product Name
FTY720 Hydrochloride
Description
S1P receptor ligand
Purity
>98% (TLC); NMR (Conforms)
CAS No.
162359-56-0
Molecular Formula
C19H34ClNO2
Molecular Weight
343.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Agonist
Solubility
Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)
Source
Synthetic
Appearance
White solid
SMILES
CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
InChI
InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChIKey
SWZTYAVBMYWFGS-UHFFFAOYSA-N
Safety Phrases
Classification: D2B Toxic Material Causing Other Toxic Effects
Moderate skin irritant
Moderate eye irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statement(s):
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H412 Harmful to aquatic life with long lasting effects.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 Avoid release to the environment.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
FTY720 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-523)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124693
Alternative Names
2-Amino-2-2-(4-octylphenyl)ethyl-1,3-propanediol,hydrochloride; Fingolimod
Research Areas
Cell Signaling
PubChem ID
107969
Scientific Background
FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug.
References
1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60.
2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7.
S1P receptor ligand
Moderate skin irritant
Moderate eye irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statement(s):
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H412 Harmful to aquatic life with long lasting effects.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 Avoid release to the environment.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7.