Forskolin__Adenylate cyclase activator SU 5402
Product Name
Forskolin
Description
Adenylate cyclase activator
Purity
>99%
CAS No.
66575-29-9
Molecular Formula
C22H34O7
Molecular Weight
410.51
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble to 100 mM in DMSO, and to 10 mM in ethanol
Source
Synthetic
Appearance
White Solid
SMILES
CC(=O)Oemail protected1email protected(C@@H2C@(email protected(CCC2(C)C)O)(C@@3(C@@1(OC@@(CC3=O)(C)C=C)C)O)C)O
InChI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,2
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H312
Precautionary Phrases:
P280
Cite This Product
Forskolin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-208)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124664
Alternative Names
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzofchromen-5-yl acetate
Research Areas
Cancer, Apoptosis
PubChem ID
47936
Scientific Background
Forskolin resensitizes cell receptors by activating adenyl cyclase, and increasing the intracellular levels of cAMP (1). Medically forskolin provides a route to inhibition of colon cancer cell growth and survival (2). It is also a vasodilator, may be helpful in controlling the cause of glaucoma (3), reduces urinary tract infections, and may help to increase the skin’s natural resistance to burning under UV light (1).
References
1. Passeron T., Namiki T., Passeron H.J., Le Pape E., and Hearing V.J. (2009) J Invest Dermatol. 129(1): 162-166.
2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11).
3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.
Adenylate cyclase activator
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H312
Precautionary Phrases:
P280
2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11).
3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.