Fumonisin B1__Ceramide synthase inhibitor MSI-1436
Product Name
Fumonisin B1
Description
Ceramide synthase inhibitor
Purity
>98%
CAS No.
116355-83-0
Molecular Formula
C34H59NO15
Molecular Weight
721.83
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 10 mM in DMSO
Source
Synthetic
Appearance
Beige Solid
SMILES
CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
InChI
InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,3
InChIKey
UVBUBMSSQKOIBE-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
R60- May impair fertility
R61- May cause harm to the unborn child
Hazard Phrases:
H351
Precautionary Phrases:
P281
Cite This Product
Fumonisin B1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-234)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124726
Alternative Names
2,2'-{(19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl)bisoxy(2-oxo-2,1-ethanediyl)}disuccinic acid
Research Areas
Cancer, Apoptosis
PubChem ID
3431
Scientific Background
Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2).
References
1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27).
2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.
Ceramide synthase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
R60- May impair fertility
R61- May cause harm to the unborn child
Hazard Phrases:
H351
Precautionary Phrases:
P281
2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.