GSK690693 Hydrochloride__AKT kinase inhibitor LEE011
Product Name
GSK690693 Hydrochloride
Description
AKT kinase inhibitor
Purity
>98% (HPLC)
CAS No.
937174-76-0
Molecular Formula
C21H27N7O3
Molecular Weight
425.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 50 mM in DMSO
Source
Synthetic
Appearance
White to beige solid
SMILES
CCN1C2=C(C(=NC=C2OCemail protected3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
InChI
InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChIKey
KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Cite This Product
GSK690693 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-448)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19127518
Alternative Names
4-2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3S)-3-piperidinylmethoxy)-1H-imidazo4,5-cpyridin-4-yl-2-methyl-3-butyn-2-ol
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
16725726
Scientific Background
GSK690693 Hydrochloride is an ATP-competitive pan-Akt kinase inhibitor. It is derived from aminofurazan. It has shown to produce antiproliferative and apoptotic effects in tumor cell lines.
References
1. Heerding D.A., et al. (2008) J. Med. Chem. 51(18): 5663–5679.
2. Rhodes N., et al. (2008) Cancer Res. 68(7): 2366–2374.
AKT kinase inhibitor
Acute toxicity, Oral (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
2. Rhodes N., et al. (2008) Cancer Res. 68(7): 2366–2374.