GW5074__c-Raf1 kinase inhibitor Cinacalcet (hydrochloride)
Product Name
GW5074
Description
c-Raf1 kinase inhibitor
Purity
>98% (TLC)
CAS No.
220904-83-6
Molecular Formula
C15H8Br2INO2
Molecular Weight
520.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 1 mM in ethanol and to 100 mM in DMSO
Source
Synthetic
Appearance
Yellow to orange solid
SMILES
C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2
InChI
InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChIKey
LMXYVLFTZRPNRV-KMKOMSMNSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
GW5074 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-451)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19127724
Alternative Names
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5924208
Scientific Background
GW5074 is a potent and selective c-Raf1 kinase inhibitor. GW5074 shows ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW5074 has been shown to block low potassium induced cell death, as well as, prevent neurodegeneration. GW5074 is cell-permeable.
References
1. Chin P.C., et al. (2004) J. Neurochem. 90(3): 595–608.
2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226.
3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.
c-Raf1 kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226.
3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.