GW 441756__NGFR kinase inhibitor Arg-Gly-Asp-Ser
Product Name
GW 441756
Description
NGFR kinase inhibitor
Purity
>99%
CAS No.
504433-23-2
Molecular Formula
C17H13N3O
Molecular Weight
275.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 15 mM in DMSO
Source
Synthetic
Appearance
Red solid
SMILES
CN1C=C(C2=CC=CC=C21)/C=C3/C4=C(C=CC=N4)NC3=O
InChI
InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-
InChIKey
NXNQLECPAXXYTR-LCYFTJDESA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
GW 441756 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-450)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19127706
Alternative Names
1,3-Dihydro-3-(1-methyl-1H-indol-3-yl)methylene-2H-pyrrolo3,2-bpyridin-2-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
9943465
Scientific Background
GW 441756 is a potent and selective NGF receptor tyrosine kinase A (TrkA) inhibitor. Specifically, it is shown to block apoptosis and cell death induced by TrkA. GW-441756 displays > 100-fold selectivity over a range of other kinases.
References
1. Wood E.R., et al. (2004) Bioorganic & Med. Chem. Ltr. 14(4): 953–957.
2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.
NGFR kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.