Galanthamine HBr

Galanthamine HBr__Acetylcholinesterase inhibitor GS967

Product Name	Galanthamine HBr
Description	Acetylcholinesterase inhibitor
Purity	>97% (HPLC); NMR (Conforms)
CAS No.	04-04-53
Molecular Formula	C17H22BrNO3
Molecular Weight	368.3

Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Product Type	Inhibitor
Solubility	Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Source	Synthetic
Appearance	White powder
SMILES	Br-.COc1ccc2CN(C)CCC@@34C=Cemail protected(O)CC@@H3Oc1c24.H+
InChI	1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChIKey	QORVDGQLPPAFRS-XPSHAMGMSA-N
Safety Phrases	Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects – Toxic by ingestion Hazard statement(s): H301 Toxic if swallowed. Precautionary statement(s): P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Cite This Product	Galanthamine HBr (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-530)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19125065

Alternative Names	Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
Research Areas	Cancer, Alzheimer_s Disease, Apoptosis, Neurodegeneration, Neuroscience
PubChem ID	121587
Scientific Background	Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice.