HC-030031__TRPA1 blocker (3R,4S)-Tofacitinib
Product Name
HC-030031
Description
TRPA1 blocker
Purity
>98%
CAS No.
349085-38-7
Molecular Formula
C18H21N5O3
Molecular Weight
355.39
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
InChI
InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChIKey
HEQDZPHDVAOBLN-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product
HC-030031 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-303)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19127745
Alternative Names
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
1150897
Scientific Background
Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).
References
1. McNamara C.R., et al. (2007) Proc Natl Acad Sci USA. 104(33): 13525-13530.
2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281.
TRPA1 blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281.