Hinokitiol__Iron Chelator antioxidant SCH 58261
Product Name
Hinokitiol
Description
Iron Chelator antioxidant
Purity
>98%
CAS No.
499-44-5
Molecular Formula
C10H12O2, C10H12O3
Molecular Weight
164.2, 165.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Antioxidant
Solubility
Soluble in DMSO or ethanol (25 mg/ml)
Source
Synthetic
Appearance
White Solid
SMILES
CC(C)C1=CC=CC(=O)C(=C1)O
InChI
InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
InChIKey
FUWUEFKEXZQKKA-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
Cite This Product
Hinokitiol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-151)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19128456
Alternative Names
2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one
Research Areas
Cancer, Oxidative Stress
PubChem ID
3611
Scientific Background
Hinokitiol is a natural monoterpenoid. It is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells (1), mediated by activation of caspase-3 (2). It also inhibits tyrosinase most likely via metal chelation (3).
References
1. Tanaka T., et al. (1999) Cell Biol Int. 23(8): 541-550.
2. Ido Y., et al. (1999) Cell Prolif. 32(1): 63-73
3. Kim D.S., et al. (2004) Arch Pharm Res. 27(3): 334-339.
Iron Chelator antioxidant
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
2. Ido Y., et al. (1999) Cell Prolif. 32(1): 63-73
3. Kim D.S., et al. (2004) Arch Pharm Res. 27(3): 334-339.