Huperzine A__ACH inhibitor AZD-9292
Product Name
Huperzine A
Description
ACH inhibitor
Purity
>95% (HPLC); NMR (conforms)
CAS No.
102518-79-6
Molecular Formula
C15H18N2O
Molecular Weight
242.32
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO, methanol or ethanol.
Source
Synthetic
Appearance
Off-White solid
SMILES
C/C=C/1C@@H2CC3=C(C@1(CC(=C2)C)N)C=CC(=O)N3
InChI
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10?,15-/m1/s1
InChIKey
ZRJBHWIHUMBLCN-JYXJEATCSA-N
Safety Phrases
Classification: Toxic
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 – Wear protective gloves/protective clothing.
P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician.
P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse.
P311 – call a POISON CENTER or doctor/physician
Cite This Product
Huperzine A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-365)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19132522
Alternative Names
(1R,9S,13E)- 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo7.3.1.02,7 trideca- 2(7),3,10- trien- 5-one
Research Areas
Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID
44461111
Scientific Background
Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer’s disease is under studies (1-3). Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate (4).
References
1. Bai Dl., Tang Xc., He YC., Curr MedChem. (2000) 7(3): 355-74.
2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.
3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.
4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.
ACH inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 – Wear protective gloves/protective clothing.
P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician.
P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse.
P311 – call a POISON CENTER or doctor/physician
2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.
3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.
4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.