Hydroxychloroquine__Autophagy inhibitor Palbociclib (isethionate)
Product Name
Hydroxychloroquine
Description
Autophagy inhibitor
Purity
>98%
CAS No.
747-36-4
Molecular Formula
C18H26ClN3O•H2SO4
Molecular Weight
433.95
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in greater than 20 mg/ml H2O.
Source
Synthetic
Appearance
White to off-white powder.
SMILES
C1=C2C(=CC(=C1)Cl)N=CC=C2NC(CCCN(CCO)CC)C.O=S(O)(O)=O
InChI
InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChIKey
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Safety Phrases
Classification: Acute toxicity, Oral (Category 4), Eye irritation (Category 2A)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H319- Causes serious eye irritation.
Precautionary statements:
P264- Wash skin thoroughly after handling.
P270- Do not eat, drink or smoke when using this product.
P280- Wear protective gloves/ eye protection/ face protection.
P301 + P312- IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P330- Rinse mouth.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P501- Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
Hydroxychloroquine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-400)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19132539
Alternative Names
Hydroxychloroquine sulphate, 7-Chloro-4-4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylaminoquinoline
Research Areas
Cancer, Autophagy
PubChem ID
12947
Scientific Background
Hydroxychloroquine was first established as an anti-malarial agent, but is now being used in a variety of applications, including the inhibition of autopagy. Hydroxychloroquine is a lysosomotropic agent and therefore inhibits autophagy by obstructing the final step of autophagy, the fusion of autophagosomes with lysosomes, thereby preventing the acidification of the lysosomal compartment. In the context of cancer, autophagy is thought to be adopted by tumor cells to survive in the nutrient-deficient and hypoxic tumor environment. Hydroxychloroquine has therefore been studied extensively within the context of certain cancers.
References
1. van Loosdregt J., et al. (2013) J Allergy Clin Immunol. 131(5): 1443-6.e1.
2. Lotze M.T., et al. (2013) Cancer J. 19(4): 341-7.
3. Xie X., et al. (2013) PLoS One. 8(1): e55096.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H319- Causes serious eye irritation.
Precautionary statements:
P264- Wash skin thoroughly after handling.
P270- Do not eat, drink or smoke when using this product.
P280- Wear protective gloves/ eye protection/ face protection.
P301 + P312- IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P330- Rinse mouth.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P501- Dispose of contents/ container to an approved waste disposal plant.
2. Lotze M.T., et al. (2013) Cancer J. 19(4): 341-7.
3. Xie X., et al. (2013) PLoS One. 8(1): e55096.