ICG-001

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ICG-001__β-catenin inhibitor TEPP-47

Product Name ICG-001
Description

β-catenin inhibitor
Purity >98%
CAS No. 847591-62-2
Molecular Formula C33H32N4O4
Molecular Weight 548.63
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
Source Synthetic
Appearance White solid
SMILES C1CN(email protected2CN(C(=O)C@@H(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
InChI InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/
InChIKey HQWTUOLCGKIECB-XZWHSSHBSA-N
Safety Phrases Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Cite This Product ICG-001 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-387)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19132637

Alternative Names (6S,9aS)-Hexahydro-6-(4-hydroxyphe­nyl)methyl-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(­phenylmethyl)-2H-pyrazino1,2-apyrimidine-1(6H)-c­arboxamide
Research Areas Cell Signaling
PubChem ID 11238147
Scientific Background Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
References 1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7.
2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53.
3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.