IOX1

IOX1__JMJD inhibitor PND-1187

Product Name	IOX1
Description	JMJD inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	5852-78-8
Molecular Formula	C10H7NO3
Molecular Weight	189.2

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (20 mg/ml)
Source	Synthetic
Appearance	Yellow powder
SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
InChI	InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChIKey	JGRPKOGHYBAVMW-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	IOX1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-377)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19133145

Alternative Names	8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
Research Areas	Cell Signaling, Epigenetics
PubChem ID	459617
Scientific Background	IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).
References	1. King O.N., et al. (2010) PLoS One. 5: e15535.