Indirubin-3′-monoxime__GSK, CDK kinase inhibitor FG-4593
Product Name
Indirubin-3′-monoxime
Description
GSK, CDK kinase inhibitor
Purity
>98% (HPLC)
CAS No.
160807-49-8
Molecular Formula
C16H11N3O2
Molecular Weight
277.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Source
Synthetic
Appearance
Red solid
SMILES
O=C/2/N=C1/C=CC=C/C1=C2c4c(NO)c3ccccc3n4
InChI
InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,19,21H
InChIKey
LDEWQRSYYHTQRA-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Indirubin-3'-monoxime (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-502)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19133018
Alternative Names
Indirubin-3'-monoxime, 3-1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene-1,3-dihydro-2H-indol-2-one, Indirubin-3′-oxime
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5326739
Scientific Background
Indirubin-3'-monoxime is an inhibitor of protein kinases and cyclin-dependent kinases. Specifically, it is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β).
References
1. Damiens E., Baratte B., Marie D., Eisenbrand G., & Meijer L. (2001) Oncogene. 20(29): 3786–3797.
GSK, CDK kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.