J9__Glucocorticoid resistance inhibitor Presatovir
Product Name
J9
Description
Glucocorticoid resistance inhibitor
Purity
99.90%
Molecular Formula
C12H12N4
Molecular Weight
212.26
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Product Type
Inhibitor
Solubility
Soluble in CDCI3
Source
Synthetic
Appearance
White Solid
SMILES
NC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1
InChI
InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)
InChIKey
PQLYPFZAOUDDHB-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
J9 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-182)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19133646
Alternative Names
4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
Research Areas
Cancer, Cell Signaling, Epigenetics
PubChem ID
PMC4094258
Scientific Background
J9, in combination with dexamethasone inhibits cell growth in T-cell acute lymphoblastic leukemia (T-ALL) through the upregulation of the glucocorticoid receptor. Patients can develop glucocorticoid resistance rendering the treatment ineffective. J9 and its mechanism of action provides a useful strategy for overcoming the resistance. The EC50 of J9 in combination with dexamethasone is 28 uM. J9 alone was less toxic.
References
1. Cantley A.M., et al. (2014) ACS Medicinal Chemistry Letters 5.7: 754-759.
Glucocorticoid resistance inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection