JX 401__p38 MAP kinase inhibitor Canagliflozin
Product Name
JX 401
Description
p38 MAP kinase inhibitor
Purity
>98% (TLC)
CAS No.
349087-34-9
Molecular Formula
C21H25NO2S
Molecular Weight
355.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml)
Source
Synthetic
Appearance
Off-white solid
SMILES
COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3
InChI
InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
InChIKey
OMGLGPKQUFSRNN-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
JX 401 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-454)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19134201
Alternative Names
1-2-Methoxy-4-(methylthio)benzoyl-4-(phenylmethyl)piperidine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
1126109
Scientific Background
JX 401 is a potent and reversible inhibitor of p38α. Specifically, it binds MAPK p38α. JX 401 is cell permeable.
References
1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405.
p38 MAP kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.