K252A__Kinase inhibitor SU5417
Product Name
K252A
Description
Kinase inhibitor
Purity
>98% (HPLC)
CAS No.
99533-80-9
Molecular Formula
C27H21N3O5
Molecular Weight
467.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 25 mM in DMSO
Source
Nonomuraea longicatena
Appearance
White solid
SMILES
N47C1=C(C6=C(C2=C1N(C3=CC=CC=C23)C@@H5OC@4(C(C5)(O)C(=O)OC)C)C(NC6)=O)C8=C7C=CC=C8
InChI
InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
InChIKey
KOZFSFOOLUUIGY-CYBHFKQVSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
K252A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-455)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19134228
Alternative Names
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo1,2,3-fg:3',2',1'-klpyrrolo3,4-i1,6benzodiazocine-10-carboxylic acid methyl ester
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
11612445
Scientific Background
K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent autophosphorylation and activation of downstream effectors.
References
1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885–4893.
2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.
3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.
Kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.
3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.