KB-R7943 mesylate

KB-R7943 mesylate__TRPC channel blocker Merimepodib

Product Name	KB-R7943 mesylate
Description	TRPC channel blocker
Purity	>98% (TLC); NMR (Conforms)
CAS No.	182004-65-5
Molecular Formula	C16H17N3O3S•CH3SO3H
Molecular Weight	427.29

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO
Source	Synthetic
Appearance	White Solid
SMILES	CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)N+(=O)O-
InChI	InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey	WGIKEBHIKKWJLG-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	KB-R7943 mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-312)

Alternative Names	2-{4-(4-Nitrobenzyl)oxyphenyl}ethyl carbamimidothioate methanesulfonate (1:1)
Research Areas	Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID	9823846
Scientific Background	KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.
References	1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749. 2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321. 3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850.