KT 5823

KT 5823__PKG kinase inhibitor TRO 19623

Product Name	KT 5823
Description	PKG kinase inhibitor
Purity	>98% (TLC)
CAS No.	126643-37-6
Molecular Formula	C29H25N3O5
Molecular Weight	495.5

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml)
Source	Synthetic
Appearance	White solid
SMILES	N47C1=C(C6=C(C2=C1N(C3=CC=CC=C23)C@@H5OC@4(C@@(C5)(OC)C(=O)OC)C)C(N(C6)C)=O)C8=C7C=CC=C8
InChI	InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3
InChIKey	QTYMDECKVKSGSM-UHFFFAOYSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	KT 5823 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-458)

Alternative Names	(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo1,2,3-fg:3',2',1'-klpyrrolo3,4-i1,6benzodiazocine-10-carboxylic acid, methyl ester
Research Areas	Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	3843
Scientific Background	KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependently inhibit spontaneous apoptosis of neutrophils.
References	1. Murthy K.S., & Makhlouf G.M. (1995) Am J. Phys. 268(1 Pt 1): C171–180. 2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501. 3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.