LDN-57444__DUB inhibitor LDN-214118
Product Name
LDN-57444
Description
DUB inhibitor
Purity
>98%
CAS No.
668467-91-2
Molecular Formula
C17H11Cl3N2O3
Molecular Weight
397.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 20 mg/ml DMSO
Source
Synthetic
Appearance
Yellow Powder
SMILES
CC(=O)O/N=C1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChI
InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChIKey
OPQRFPHLZZPCCH-PGMHBOJBSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves.
Cite This Product
LDN-57444 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-332)
Alternative Names
3-(O-acetyloxime), 5-chloro-1-(2,5-dichlorophenyl)methyl-1H-Indole-2,3-dione, C30, LDN 57444
Research Areas
Cancer, Apoptosis
PubChem ID
16760696
Scientific Background
Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
References
1. Liu Y., et al. (2003) Chem. Biol. 10: 837.
2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.
3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.
DUB inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves.
2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.
3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.