LFM A13__BTK kinase inhibitor CFI-400946 (free base)
Product Name
LFM A13
Description
BTK kinase inhibitor
Purity
>97% (TLC)
CAS No.
62004-35-7
Molecular Formula
C11H8Br2N2O2
Molecular Weight
360.0
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (10 mg/ml) or ethanol (0.3 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
C/C(=C(C#N)/C(=O)NC1=C(C=CC(=C1)Br)Br)/O
InChI
InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)
InChIKey
UVSVTDVJQAJIFG-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
LFM A13 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-461)
Alternative Names
2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
54686938
Scientific Background
LFM A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK).
References
1. Vassilev A., Ozer Z., Navara C., Mahajan S., & Uckun F.M. (1999). J. Biol. Chem. 274(3): 1646–1656.
BTK kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.