LH 846__Casein kinase 1d inhibitor Integrin Antagonist 2 (hydrochloride)
Product Name
LH 846
Description
Casein kinase 1d inhibitor
Purity
>98% (HPLC)
CAS No.
639052-78-1
Molecular Formula
C16H13ClN2OS
Molecular Weight
316.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White to beige powder
SMILES
CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
InChI
InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
InChIKey
DYHAMRNAHTWYKY-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4)
Chronic aquatic toxicity(Category 4)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
H413 May cause long lasting harmful effects to aquatic life.
Cite This Product
LH 846 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-503)
Alternative Names
LH846, LH-846, N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Research Areas
Cell Signaling
PubChem ID
851474
Scientific Background
LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm.
References
1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611.
Casein kinase 1d inhibitor
Acute toxicity, Oral (Category 4)
Chronic aquatic toxicity(Category 4)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
H413 May cause long lasting harmful effects to aquatic life.