LYS6K2__S6 kinase inhibitor Bafetinib
Product Name
LYS6K2
Description
S6 kinase inhibitor
Purity
97% (HPLC)
Molecular Formula
C21H19F4N7
Molecular Weight
445.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming)
Source
Synthetic
Appearance
Yellow solid
SMILES
Cn1cc(nc1C2CCN(CC2)c3c4cnnHc4ncn3)c5ccc(c(c5)C(F)(F)F)F
InChI
InChI=1S/C21H19F4N7/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30)
InChIKey
FYXRSVDHGLUMHB-UHFFFAOYSA-N
Safety Phrases
Classification:
Skin Category 2
Eye Category 2A
Specific target organ toxicity – single exposure (Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Cite This Product
LYS6K2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-462)
Alternative Names
4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo 3,4-d pyrimidine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
25118925
Scientific Background
LYS6K2 is a selective inhibitor of the p70 ribosomal S6 kinase. Specifically, it blocks the phosphorylation of S6. LYS6K2 is cell permeable.
References
1. Fenton T.R., & Gout I.T. (2011) Int. J. Biochem. Cell Biol. 43(1): 47–59.
S6 kinase inhibitor
Skin Category 2
Eye Category 2A
Specific target organ toxicity – single exposure (Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.