Lactacystin__Proteasome inhibitor LY2801654 (dihydrochloride)
Product Name
Lactacystin
Description
Proteasome inhibitor
Purity
>98%
CAS No.
133343-34-7
Molecular Formula
C15H24N2O7S
Molecular Weight
376.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO, Water or Ethanol
Source
Synthetic
Appearance
White Solid
SMILES
CC@@H1C@@H(C(NC1=O)(email protected(C(C)C)O)C(=O)SCC@@H(C(=O)O)NC(=O)C)O
InChI
InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
InChIKey
DAQAKHDKYAWHCG-RWTHQLGUSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Lactacystin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-327)
Alternative Names
(2R,3S,4R)-3-Hydroxy-2-(1S)-1-hydroxy-2-methylpropyl-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID
6610292
Scientific Background
Specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Peptidyl-glutamyl peptide hydrolytic activity is relatively weak.
References
1. Omura S., et al. (1991) J. Antibiot. 44: 113.
2. Fenteany G., et al. (1995) Science 268: 726
Proteasome inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Fenteany G., et al. (1995) Science 268: 726