Leflunomide__Immunosupressant Z-VAD-FMK
Product Name
Leflunomide
Description
Immunosupressant
Purity
>98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65); NMR (Conforms)
CAS No.
75706-12-6
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml)
Source
Synthetic
Appearance
White crystalline solid
SMILES
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
InChI
InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChIKey
VHOGYURTWQBHIL-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R25 – Toxic if swallowed
R62 – Possible risk of impaired fertility
R63 – Possible risk of harm to the unborn child
Hazard Phrases:
H301 – Toxic if swallowed.
H315 – Causes skin irritation.
H319 – Causes serious eye irritation
H335 – May cause respiratory irritation
Precautionary Phrases:
P264 – Wash hands thoroughly after handling
P280 – Wear protective gloves/protective clothing/eye protection/ face protection
P301+310 – IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P308+313 – If exposed or concerned: Get medical advice/attention
Cite This Product
Leflunomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-368)
Alternative Names
5-methyl-N-4-(trifluoromethyl) phenyl-isoxazole-4-carboxamide
Research Areas
Cell Signaling, Neuroscience
PubChem ID
3899
Scientific Background
Leflunomide is an Immuno-suppressant, it inhibits de novo synthesis of pyrimidine nucleotides and the activity of the protein kinase. It is a part of the known “disease-modifying anti-rheumatic drugs” (DMARD). It has been suggested that leflunomide modulates the expansion of activated autoimmune lymphocytes acting on the regression of rheumatoid conditions (1-2). It has been shown to have a double mechanism of action by slowing down and relieving the pain of rheumatoid arthritis. Studies have shown the lethal effects of Leflunomide after administration to mice in various doses (3).
References
1. Fukushima R., Kanamori S., Hirashiba M., et al. (2007) Reprod. Toxical. 24(3-4): 310-316.
2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56.
3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.
Immunosupressant
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R25 – Toxic if swallowed
R62 – Possible risk of impaired fertility
R63 – Possible risk of harm to the unborn child
Hazard Phrases:
H301 – Toxic if swallowed.
H315 – Causes skin irritation.
H319 – Causes serious eye irritation
H335 – May cause respiratory irritation
Precautionary Phrases:
P264 – Wash hands thoroughly after handling
P280 – Wear protective gloves/protective clothing/eye protection/ face protection
P301+310 – IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P308+313 – If exposed or concerned: Get medical advice/attention
2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56.
3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.