Lenalidomide__Ubiquitin ligase inducer Sumanirole (maleate)
Product Name
Lenalidomide
Description
Ubiquitin ligase inducer
Purity
>98% (TLC); NMR (Conforms)
CAS No.
191732-72-6
Molecular Formula
C13H13N3O3
Molecular Weight
259.26
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in DMSO (200 mM), Water (<1 mM) and Ethanol (<1 mM).
Source
Synthetic
Appearance
Powder
SMILES
C1=CC=C(C3=C1C(N(C2C(NC(=O)CC2)=O)C3)=O)N
InChI
InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Safety Phrases
Classification: Acute toxicity, Oral (Category 4), Acute toxicity, Dermal (Category 4), Acute toxicity, Inhalation (Category 4), Reproductive toxicity (Category 1B)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301- Harmful if swallowed.
H312- Harmful in contact with skin.
H332- Harmful if inhaled.
H360-May damage fertility or the unborn child.
Precautionary statements:
P261- Avoid breathing dust/fumes/gas/mist/vapors/spray.
P263- Avoid contact during pregnancy/while nursing.
P270- Do not eat, drink or smoke when using this product.
P280- Wear protective gloves/protective clothing.
P301+P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352- IF ON SKIN: Wash with plenty of soap and water.
P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+P313- IF exposed or concerned: Get medical advice/attention.
P330- Rinse mouth.
P405- Store locked up.
P501- Dispose of contents/container to a licensed disposal company.
Cite This Product
Lenalidomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-410)
Alternative Names
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Research Areas
Cell Signaling, Post-translational Modifications
PubChem ID
216326
Scientific Background
Clinically, lenalidomide has proven to be effective in the treatment of multiple myeloma and other B cell diseases. It has the ability to selectively bind and ubiquitinate two lymphoid transcription factors, IKZF1 and IKZF2, via the CRBN-CRL4 ubiquitin ligase. This ultimately leads to the degradation of IKZF1 and IKZF2, which are both essential in myeloma cell survival.
References
1. Krönke J., et al. (2014) Science. 343(6168): 301-5.
2. Lu G., et al. (2014) Science. 343(6168): 305-9.
Ubiquitin ligase inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301- Harmful if swallowed.
H312- Harmful in contact with skin.
H332- Harmful if inhaled.
H360-May damage fertility or the unborn child.
Precautionary statements:
P261- Avoid breathing dust/fumes/gas/mist/vapors/spray.
P263- Avoid contact during pregnancy/while nursing.
P270- Do not eat, drink or smoke when using this product.
P280- Wear protective gloves/protective clothing.
P301+P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352- IF ON SKIN: Wash with plenty of soap and water.
P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+P313- IF exposed or concerned: Get medical advice/attention.
P330- Rinse mouth.
P405- Store locked up.
P501- Dispose of contents/container to a licensed disposal company.
2. Lu G., et al. (2014) Science. 343(6168): 305-9.