Leptomycin B__Nuclear export inhibitor Lu AE58055 (Hydrochloride)
Product Name
Leptomycin B
Description
Nuclear export inhibitor
Purity
>99% (HPLC); NMR (Conforms)
CAS No.
87081-35-4
Molecular Formula
C33H48O6
Molecular Weight
540.7
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved into DMSO or ethanol. Use solutions made with DMSO within 24 hours.
Source
Synthetic
Appearance
Solution in ethanol (0.2 mg/ml)
SMILES
CCC(/C=C/email protected1OC(=O)C=CC@@H1C)=C/email protected(C)CC=CC(C)=CC@@H(C)C(=O)C@@H(C)email protected(O)C@@H(C)CC(C)=CC(O)=O
InChI
1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-
InChIKey
YACHGFWEQXFSBS-NRQIOVFOSA-N
Safety Phrases
Classification:
B2 Flammable liquid – Flammable liquid
D1B Toxic Material Causing Immediate and Serious Toxic Effects – Toxic by ingestion, Toxic by skin absorption
Hazard statement(s):
H225 Highly flammable liquid and vapour.
H301 + H311 Toxic if swallowed or in contact with skin
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H370 Causes damage to organs.
Precautionary statement(s):
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.
Cite This Product
Leptomycin B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-534)
Alternative Names
Elactocin, LMB, Mantuamycin, NSC 364372
Research Areas
Cancer, Cancer Growth Inhibitors
PubChem ID
6917907
Scientific Background
Leptomycin B is an inhibitor of nuclear export proteins. It is an anti-fungal, and anti-tumor cytotoxin.
Nuclear export inhibitor
B2 Flammable liquid – Flammable liquid
D1B Toxic Material Causing Immediate and Serious Toxic Effects – Toxic by ingestion, Toxic by skin absorption
Hazard statement(s):
H225 Highly flammable liquid and vapour.
H301 + H311 Toxic if swallowed or in contact with skin
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H370 Causes damage to organs.
Precautionary statement(s):
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.