Lestaurtinib__FLT3, TrkA kinase inhibitor Grapiprant
Product Name
Lestaurtinib
Description
FLT3, TrkA kinase inhibitor
Purity
>98% (HPLC)
CAS No.
111358-88-4
Molecular Formula
C26H21N3O4
Molecular Weight
439.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source
Synthetic
Appearance
White powder
SMILES
C@@67(N2C1=C5C(=C4C(=C1C3=C2C=CC=C3)CNC4=O)C8=C(N5email protected(O6)CC@7(O)CO)C=CC=C8)C
InChI
InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
InChIKey
UIARLYUEJFELEN-LROUJFHJSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Lestaurtinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-460)
Alternative Names
KT5555, CEP-701, (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo1,2,3-fg:3',2',1'-klpyrrolo3,4-i1,6benzodiazocin-1-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
126565
Scientific Background
Lestaurtinib is potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor. Specifically, it prevents STAT5 phosphorylation. Lestaurtinib exhibits antiproliferative activity in vitro.
References
1. Weisel K.C., et al. (2007) Ann. NY Acad. Sci. 1106: 190–196.
2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.
FLT3, TrkA kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.