MG-132__Proteasome Inhibitor LCL162
Product Name
MG-132
Description
Proteasome Inhibitor
Purity
>98%
CAS No.
133407-82-6
Molecular Formula
C26H41N3O5, C26H41N3O6
Molecular Weight
475.6, 476.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 45 mg/ml DMSO, DMF and ethanol
Source
Synthetic
Appearance
White solid
SMILES
CC(C)CC@@H(C=O)NC(=O)email protected(CC(C)C)NC(=O)email protected(CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0
InChIKey
TZYWCYJVHRLUCT-VABKMULXSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
MG-132 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-326)
Alternative Names
N-(Benzyloxy)carbonyl-L-leucyl-N-(2S)-4-methyl-1-oxo-2-pentanyl-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-(phenylmethoxy)carbonyl-L-leucyl-N-(1S)-1-formyl-3-methylbutyl-L-leucinamide
Research Areas
Cancer, Heat Shock
PubChem ID
462382
Scientific Background
Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable
References
1. Tsubuki S., et al. (1996) J. Biochem. 119:572.
2. Wu W.K., et al. (2010) Autophagy 6:228.
3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.
Proteasome Inhibitor
Safety Phrases:
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Wu W.K., et al. (2010) Autophagy 6:228.
3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.