Mitomycin C__DNA synthesis inhibitor CB-5084
Product Name
Mitomycin C
Description
DNA synthesis inhibitor
Purity
>98%
CAS No.
50-07-7
Molecular Formula
C15H18N4O5
Molecular Weight
334.33
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO, 5 mM water, and to 5 mM Ethanol
Source
Synthetic
Appearance
Dark Purple Crystalline Solid
SMILES
CC1=C(C(=O)C2=C(C1=O)N3Cemail protected4C@@H(C@@3(C@@H2COC(=O)N)OC)N4)N
InChI
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H
InChIKey
NWIBSHFKIJFRCO-WUDYKRTCSA-N
Safety Phrases
Classification: Very toxic. May be fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R26/27/28 – Very Toxic by inhalation, in contact with skin and if swallowed
R46 – May cause heritable genetic damage
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H351
Precautionary Phrases:
P281
Cite This Product
Mitomycin C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-246)
Alternative Names
(1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno2',3':3,4pyrrolo1,2-aindol-8-ylmethyl carbamate, Ametycine
Research Areas
Cancer, Apoptosis
PubChem ID
5746
Scientific Background
The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5’-CpG-3’ (1).
References
1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.
DNA synthesis inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R26/27/28 – Very Toxic by inhalation, in contact with skin and if swallowed
R46 – May cause heritable genetic damage
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H351
Precautionary Phrases:
P281