Montelukast sodium__Leukotriene CysLT1 antagonist SJG-137
Product Name
Montelukast sodium
Description
Leukotriene CysLT1 antagonist
Purity
>98% (HPLC); NMR (conforms)
CAS No.
151767-02-1
Molecular Formula
C35H35ClNO3S • Na
Molecular Weight
608.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Antagonist
Solubility
Soluble in DMSO (50 mg/ml), or water (30 mg/ml), or ethanol (60 mg/ml)
Source
Synthetic
Appearance
Powder
SMILES
CC(C)(O)C(C=CC=C1)=C1CCemail protected(SCC2(CC2)CC(O-)=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.Na+
InChI
1S/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(
InChIKey
LBFBRXGCXUHRJY-YBGTYPRZSA-M
Safety Phrases
Classification:
D2A Very Toxic Material Causing Other Toxic Effects – Reproductive hazard
E Corrosive Material – Corrosive to skin
Hazard statement(s):
H318 Causes serious eye damage.
H361fd Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary statement(s):
P280 Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
Montelukast sodium (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-538)
Alternative Names
1-(1R)-1-3-(1E)-2-(7-chloro-2-quinolinyl)ethenylphenyl-3-2-(1-hydroxy-1-methylethyl)phenylpropylthio-methyl-cyclopropaneacetic acid, monosodium salt, Montelukast sodium, Montelukast monosodium salt, MK-0476, MK-476, KS-1087
Research Areas
Immunology, Innate Immunity, Macrophage
PubChem ID
23663996
Scientific Background
Montelukast is a cysteinyl leukotriene receptor 1 (CysLT1) antagonist. It blocks pentylenetetrazole-induced seizures, blood brain barrier disruption and leukocyte migration in mice.
Leukotriene CysLT1 antagonist
D2A Very Toxic Material Causing Other Toxic Effects – Reproductive hazard
E Corrosive Material – Corrosive to skin
Hazard statement(s):
H318 Causes serious eye damage.
H361fd Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary statement(s):
P280 Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.