Myriocin (ISP-1)__Palmitoyltransferase inhibitor Quisinostat
Product Name
Myriocin (ISP-1)
Description
Palmitoyltransferase inhibitor
Purity
>98%
CAS No.
35891-70-4
Molecular Formula
C21H39NO6
Molecular Weight
401.54
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml;
heat briefly in boiling water
bath) or in dilute base
(5 mg/ml; 50 mM NaOH)
Source
Synthetic
Appearance
Off-White Solid
SMILES
CCCCCCC(=O)CCCCCC/C=C/Cemail protected(C@@H(C@@(CO)(C(=O)O)N)O)O
InChI
InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
InChIKey
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label wherepossible)
Risk Phrases:
R22- Harmful if swallowed
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product
Myriocin (ISP-1) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-233)
Alternative Names
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid
Research Areas
Cancer, Apoptosis
PubChem ID
6438394
Scientific Background
Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2).
References
1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641.
2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.
Palmitoyltransferase inhibitor
heat briefly in boiling water
bath) or in dilute base
(5 mg/ml; 50 mM NaOH)
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label wherepossible)
Risk Phrases:
R22- Harmful if swallowed
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.