Necrostatin__Necroptosis inhibitor LY2157300
Product Name
Necrostatin
Description
Necroptosis inhibitor
Purity
>98%
CAS No.
4311-88-0
Molecular Formula
C13H13N3OS
Molecular Weight
259.33
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 15 mM in ethanol, and to 30 mM in DMSO
Source
Synthetic
Appearance
Light Yellow Solid
SMILES
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChI
InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChIKey
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Necrostatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-213)
Alternative Names
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1
Research Areas
Cancer, Apoptosis
PubChem ID
2828334
Scientific Background
Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
References
1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573.
2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.
3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.
Necroptosis inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.
3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.