Niclosamide__Autophagy inducer I-BET152
Product Name
Niclosamide
Description
Autophagy inducer
Purity
>98% (TLC); NMR (Conforms)
CAS No.
50-65-7
Molecular Formula
C13H8Cl2N2O4
Molecular Weight
327.12
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 25 mM in ethanol and to 10 mM in DMSO
Source
Synthetic
Appearance
Pale yellow solid
SMILES
C2=C(C(NC1=C(C=C(N+(=O)O-)C=C1)Cl)=O)C(=CC=C2Cl)O
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChIKey
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Niclosamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-406)
Alternative Names
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Research Areas
Cancer, Autophagy
PubChem ID
4477
Scientific Background
Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
References
1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.