S. J Comp Neurol 493: 6371. 26. Morton GJ, Cummings DE, Baskin DG, 15857111 Barsh GS, Schwartz MW Central nervous system manage of food intake and physique weight. Nature 443: 289295. 27. Flier JS Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337350. 28. Wauters M, Considine RV, Van Gaal LF Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 143: 293311. 29. Garofalo C, Surmacz E Terlipressin manufacturer Leptin and cancer. J Cell Physiol 207: 1222. 30. Cirillo D, Rachiglio AM, la Montagna R, Giordano A, Normanno N Leptin signaling in AZ 876 breast cancer: an overview. J Cell Biochem 105: 956964. 31. Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, et al. Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study. Ann Oncol 19: 384389. 32. Frankenberry KA, Skinner H, Somasundar P, McFadden DW, Vona-Davis LC Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28: 985993. 33. Ray A, Cleary MP Leptin as a possible therapeutic target for breast cancer prevention and therapy. Professional Opin Ther Targets 14: 443451. 34. Choi JH, Choi KC, Auersperg N, Leung Pc Overexpression of folliclestimulating hormone receptor activates oncogenic pathways in preneoplastic ovarian surface epithelial cells. J Clin Endocrinol Metab 89: 55085516. 35. Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, et al. A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction within the postinfarcted rat heart. Am J Physiol Heart Circ Physiol 295: H441446. 36. Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, et al. Leptin enhance in multiple sclerosis associates with decreased quantity of CD4CD25+ regulatory T cells. Proc Natl Acad Sci U S A 102: 51505155. 37. De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, et al. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 116: 447455. 38. Iversen PO, Drevon CA, Reseland JE Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood one hundred: 41234128. 39. Rene Gonzalez R, Watters A, Xu Y, Singh UP, Mann DR, et al. Leptinsignaling inhibition benefits in effective anti-tumor activity in estrogen receptor constructive or negative breast cancer. Breast Cancer Res 11: R36. 40. Brandon EL, Gu JW, Cantwell L, He Z, Wallace G, et al. Obesity promotes melanoma tumor development: function of leptin. Cancer Biol Ther eight: 1871 1879. 41. Muruganandam A, Tanha J, Narang S, Stanimirovic D Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J 16: 240242. 42. Munzberg H, Flier JS, Bjorbaek C Region-specific leptin resistance inside the hypothalamus of diet-induced obese mice. Endocrinology 145: 48804889. 43. Faouzi M, Leshan R, Bjornholm M, Hennessey T, Jones J, et al. Differential accessibility of circulating leptin to person hypothalamic web pages. Endocrinology 1846921 148: 54145423. 44. Cheunsuang O, Morris R Astrocytes inside the arcuate nucleus and median eminence that take up a fluorescent dye in the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52: 228233. 45. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, et al. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142: 43894393. 46. Lammert A, Kiess W, Bottner A, Glasow A,.S. J Comp Neurol 493: 6371. 26. Morton GJ, Cummings DE, Baskin DG, 15857111 Barsh GS, Schwartz MW Central nervous technique control of meals intake and body weight. Nature 443: 289295. 27. Flier JS Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337350. 28. Wauters M, Considine RV, Van Gaal LF Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 143: 293311. 29. Garofalo C, Surmacz E Leptin and cancer. J Cell Physiol 207: 1222. 30. Cirillo D, Rachiglio AM, la Montagna R, Giordano A, Normanno N Leptin signaling in breast cancer: an overview. J Cell Biochem 105: 956964. 31. Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, et al. Melanoma danger in association with serum leptin levels and life style parameters: a case-control study. Ann Oncol 19: 384389. 32. Frankenberry KA, Skinner H, Somasundar P, McFadden DW, Vona-Davis LC Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28: 985993. 33. Ray A, Cleary MP Leptin as a prospective therapeutic target for breast cancer prevention and therapy. Professional Opin Ther Targets 14: 443451. 34. Choi JH, Choi KC, Auersperg N, Leung Pc Overexpression of folliclestimulating hormone receptor activates oncogenic pathways in preneoplastic ovarian surface epithelial cells. J Clin Endocrinol Metab 89: 55085516. 35. Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, et al. A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction within the postinfarcted rat heart. Am J Physiol Heart Circ Physiol 295: H441446. 36. Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, et al. Leptin boost in many sclerosis associates with decreased number of CD4CD25+ regulatory T cells. Proc Natl Acad Sci U S A 102: 51505155. 37. De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, et al. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 116: 447455. 38. Iversen PO, Drevon CA, Reseland JE Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood 100: 41234128. 39. Rene Gonzalez R, Watters A, Xu Y, Singh UP, Mann DR, et al. Leptinsignaling inhibition results in efficient anti-tumor activity in estrogen receptor constructive or adverse breast cancer. Breast Cancer Res 11: R36. 40. Brandon EL, Gu JW, Cantwell L, He Z, Wallace G, et al. Obesity promotes melanoma tumor growth: function of leptin. Cancer Biol Ther eight: 1871 1879. 41. Muruganandam A, Tanha J, Narang S, Stanimirovic D Collection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J 16: 240242. 42. Munzberg H, Flier JS, Bjorbaek C Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145: 48804889. 43. Faouzi M, Leshan R, Bjornholm M, Hennessey T, Jones J, et al. Differential accessibility of circulating leptin to individual hypothalamic websites. Endocrinology 1846921 148: 54145423. 44. Cheunsuang O, Morris R Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye in the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52: 228233. 45. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, et al. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142: 43894393. 46. Lammert A, Kiess W, Bottner A, Glasow A,.