“classic” methods also as PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22219426?dopt=Abstract their distinguishing elements. In all regular C-based protocols, chromatin is very first cross-linked, most frequently by using formaldehyde as a fixative (see Fig. ; Dekker et al.). The cross-linked chromatin is then fragmented. While MNase was not too long ago introduced inside a modified Hi-C process named Micro-C to …
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