AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This can be a representative sample of 20 current studies located on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures obtaining potential application for early disease detection. Studies with fewer than 20 BC cases were excluded. Although these signatures primarily reflect larger amounts of circulating miRNAs, some miRNAs are detected at reduced levels in blood samples of BC sufferers. Blood collection was performed ahead of surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the least 3 independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated threat loci linked to BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians purchase SCR7 Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No threat CBR-5884 chemical information association Protective dar.12324 elevated risk Decreased danger No threat association Decreased danger Decreased danger Decreased risk No risk association No threat association improved survival No danger association Decreased general danger improved risk increased risk No threat association elevated overall danger Decreased danger of eR+ BC No danger association earlier age of onset No danger association No threat association No danger association No risk association Decreased threat (C allele) No danger association No danger association No threat association No danger association No danger association No threat association No threat association No danger association Decreased risk Reduced danger Survival of HeR2+ situations No risk association Decreased danger No risk association Decreased danger Decreased risk Decreased risk enhanced danger improved danger No threat association No threat association No risk association No danger association Decreased risk of eR- BC No risk association increased survival elevated danger of eR- BC No danger association No risk association increased overall danger No danger association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Main transcript Major transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: That is a representative sample of 20 current research found on a PubMed query (breast cancer blood miRNA miR) that describe person miRNAs or miRNA signatures obtaining prospective application for early disease detection. Studies with fewer than 20 BC instances have been excluded. Although these signatures mainly reflect higher amounts of circulating miRNAs, some miRNAs are detected at reduce levels in blood samples of BC sufferers. Blood collection was performed ahead of surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in a minimum of three independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated threat loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No risk association Protective dar.12324 enhanced risk Decreased danger No danger association Decreased danger Decreased threat Decreased risk No risk association No risk association increased survival No danger association Decreased all round threat elevated threat improved risk No risk association increased overall danger Decreased threat of eR+ BC No danger association earlier age of onset No risk association No threat association No risk association No danger association Decreased threat (C allele) No risk association No risk association No risk association No threat association No risk association No threat association No threat association No risk association Decreased danger Reduced danger Survival of HeR2+ cases No danger association Decreased threat No danger association Decreased threat Decreased risk Decreased risk elevated risk improved risk No danger association No danger association No danger association No danger association Decreased threat of eR- BC No risk association elevated survival elevated danger of eR- BC No risk association No threat association improved general risk No danger association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Key transcript Principal transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.