Oned3 cycles, ten min day for 1 dayAt the exact same time as reperfusionBilateral femoral arteriesp38MAPK signal pathway(80)(Continued)Frontiers in Neurology | www.frontiersin.org 7 February 2018 | Volume 9 | ArticleChen et al.TABLe 1 | Continued Animal Sex, age, body weight Male, 9 weeks old, 29020 g ischemic organ Heart Anesthetic utilized prior to ischemia Pentobarbital 60 mgkg Anesthetic used in the course of RiC Not described RiC protocolday when RiC was began RiC organ Principal pathway investigated pioid receptors ReferenceSD rats1 cycle, 10 min ischemia, 5 min reperfusionday for 1 dayTwo hind limbs At 15 min soon after left coronary artery ligation, and limb blood supply was restored 5 min prior to loosening the left coronary artery ligation for myocardial reperfusion. At 24 h soon after hypoxia ischemia. Heart ischemia was induced immediately following LRIpreC At 24 h SNX-5422 MedChemExpress before ischemia Brain ischemia was induced promptly following LRIpreC Brain ischemia was induced at 1 h immediately after LRIpreC Hind limb(81)SD ratsUnsexed Brain pups, ten days Male, 10 days old Heart3 Isoflurane and maintained with 1.five 3 Isoflurane and maintained with 1.five Pentobarbital 70 mgkg 5 Isoflurane and maintained with two 4 Isoflurane and maintained with 21.5 Isoflurane4 cycles, 10 min day for 1 day four cycles, 5 minday for 1 dayNo precise pathway talked about By systemic releasing of microRNA(66)Limb remote ischemic preconditioning (LRIpreC)C57BL6 micePentobarbital 60 mgkgHind limb(82)C57BL6 mice SD ratsMale, 92 weeks Male, 25050 g Male, 280Heart BrainNot described two Isoflurane two Isoflurane3 cycles, five minday for 1 day 3 cycles, 15 min day for 1 day 3 cycles, five minday for 1 dayLeft femoral artery Left hind limbBy upregulating IL10 No certain pathway pointed out Depend on the activation of adenosine A1 receptors and by reduction in oxidative pressure, inflammation and endogenous antioxidant preservation No distinct pathway talked about(83) (84)SD ratsBrainRight hind limb(85)Wistar ratsMale, 25080 gBrain10 Chloral HydrateNot mentioned3 cycles five min; three sessionsday for three days two cycles, 5 or 15 min (two cycles, five min; three cycles, five min; 2 cycles 15 min, 3 cycles 15 min)day for 1 day 3 cycles, five minday for 3 daysBrain ischemia was induced immediately right after the final LRIpreC operationLeft widespread carotid artery(86)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 11 IsofluraneBrain ischemia was Left hind limb induced right away or 12 h, two d following LRIpreCNo specific pathway described(41) Remote Ischemic ConditioningWistar ratsMale, 24060 gHeartUrethane 1 gkgChloral Hydrate 0.3 gkgAt dayLeft hind limbDecreased leakage of myocardial enzymes(87) (Continued)TABLe 1 | Continued Animal Sex, age, body weight Male, 28020 g Unsexed pups, 15000 g Male, 80 weeks ischemic organ Brain Anesthetic made use of prior to ischemia 5 Isoflurane and maintained with two.five Thiopental 35 mgkg Pentobarbital 60 mgkg Anesthetic employed for the duration of RiC 2.5 Isoflurane RiC protocolday when RiC was began At 1 h ahead of middle cerebral artery occlusion (MCAO) At 10 min just before the heart ischemia Collected blood sample at five min ( LRIpreC5) or ten min (LRIpreC10) after limb ischemia RiC organ Principal pathway investigated Important alterations in peripheral immune responses TRPV1 channels ReferenceFrontiers in Neurology | www.frontiersin.org 8 February 2018 | Volume 9 | ArticleChen et al.SD rats4 cycles, five minday for 1 day 4 cycles, five minday for 1 day 10 min limb ischemia followed by five min (LRIpreC5) or ten min (LRIpreC10) reperfusionday for 1 day three cycles, 15.