Ters, CSIR-HRDC Campus Sector 19, Kamala Nehru Nagar, Ghaziabad 201002, India Correspondence: [email protected]; Tel.: +61-3-9925-Citation: Jakku, R.K.; Mirzadeh, N.; Priv , S.H.; Reddy, G.; Vardhaman, A.K.; Lingamallu, G.; Trivedi, R.; Bhargava, S.K. TetraphenylethyleneSubstituted Bis(thienyl)imidazole (DTITPE), An Effective Molecular Sensor for the Detection and Quantification of Fluoride Ions. Chemosensors 2021, 9, 285. https:// doi.org/10.3390/chemosensors9100285 Academic Editors: Valerio Leupeptin hemisulfate Autophagy Vignoli and Enza PanzardiAbstract: Fluoride ion plays a pivotal part in a selection of biological and chemical applications having said that excessive Imeglimin Reactive Oxygen Species,Mitochondrial Metabolism exposure may cause severe kidney and gastric difficulties. A very simple and selective molecular sensor, 4,5-di(thien-2-yl)-2-(4-(1,two,2-triphenylvinyl)-phenyl)-1H-imidazole, DTITPE, has been synthesized for the detection of fluoride ions, with detection limits of 1.37 10- 7 M and 2.67 10-13 M, determined by UV-vis. and fluorescence spectroscopy, respectively. The variation inside the optical properties on the molecular sensor inside the presence of fluoride ions was explained by an intermolecular charge transfer (ICT) approach involving the bis(thienyl) and tetraphenylethylene (TPE) moieties upon the formation of a N-H–F- hydrogen bond of your imidazole proton. The sensing mechanism exhibited by DTITPE for fluoride ions was confirmed by 1 H NMR spectroscopic research and density functional theory (DFT) calculations. Test strips coated with the molecular sensor can detect fluoride ions in THF, undergoing a color adjust from white to yellow, which is usually observed together with the naked eye, showcasing their potential real-world application. Keywords and phrases: bis(thienyl) imidazole; tetraphenylethylene; molecular sensor; fluoride anion; fluorescenceReceived: 23 July 2021 Accepted: 28 September 2021 Published: 6 OctoberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.1. Introduction The detection and recognition of anionic analytes has created into an extremely active analysis field in current years [14]. Anions play a crucial role in a array of biological and chemical processes, and their detection, even at really low concentrations, has been the motivation for continuous improvement in sensor improvement more than the final couple of decades [15,16]. In accordance with the earlier literature, the probable toxic dose (PTD) of fluoride was defined at five mg/kg of physique mass. The PTD may be the minimal dose that could trigger really serious and life-threatening indicators and symptoms which demand instant remedy and hospitalization [17]. The fluoride anion, possessing the smallest ionic radii, hard Lewis basic nature and higher charge density, has emerged as an attractive topic for sensor design and style on account of its association using a wide range of organic, medicinal, and technological procedures. In addition, fluoride ions play a considerable function in dental well being [18] and has been utilized for the remedy of osteoporosis [191] and for military uses, such as the refinement of uranium for nuclear weapons [22]. It is actually readily absorbed by the human bodyCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access post distributed beneath the terms and situations with the Inventive Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ four.0/).Chemosensors 2021, 9, 285. https://doi.org/10.3390/chemosensorshttps://www.mdpi.com/journal/chemosensorsChemosensors 20.