-BailDepartment of Genetics, Gregor Mendel Constructing, Faculty of Science, Campus Rabanales
-BailDepartment of Genetics, Gregor Mendel Developing, Faculty of Science, Campus Rabanales, University of C doba, 14014 C doba, Spain; [email protected] (M.-D.L.-B.); [email protected] (A.-M.) Division of Plant Breeding, Institute of Sustainable Nitrocefin Autophagy Agriculture, CSIC, Avd. Men dez Pidal s/n, 14004 C doba, Spain; [email protected] (S.O.-C.); [email protected] (A.d.H.-B.) Correspondence: [email protected]; Tel.: +34-9-5721-8674; Fax: +34-9-5721-Citation: Merinas-Amo, T.; Lozano-Baena, M.-D.; Obreg -Cano, S.; Alonso-Moraga, ; de Haro-Bail , A. Role of Glucosinolates in the Nutraceutical Potential of Chosen Cultivars of Brassica rapa. Foods 2021, ten, 2720. https://doi.org/10.3390/ foods10112720 Academic MNITMT References Editor: Youn Young Shim Received: 8 October 2021 Accepted: 5 November 2021 Published: 7 NovemberAbstract: Brassica rapa L. subsp. rapa (turnip greens), a traditionally consumed vegetable, is wellknown because of its higher content material of glucosinolates, which are secondary metabolites with a constructive biological activity for human health. Our hypothesis has been based on the relation in between B. rapa glucosinolate content material and its healthy properties, and our aim is to establish guidelines for safe B. rapa vegetable consumption. 3 B. rapa cultivars (143N5, 143N7 and 163N7) have already been characterized by HPLC evaluation of purified extracts from leaf samples as a way to ascertain their glucosinolate content material and to relate this content material to beneficial effects on DNA protection, lifespan extension and chemoprevention. In order to ascertain the heath properties in vitro and in vivo, toxicity activities have been assayed within the Drosophila melanogaster and leukaemia cell models; genomic security was also assessed in each models utilizing genotoxicity, fragmentation and comet assay. The Drosophila model has also been made use of to study the antioxidative activity plus the longevity induction. Our outcomes showed a connection involving B. rapa glucosinolate content and its safety and benefices in its consumption. Gluconapin, the principle B. rapa glucosinolate, was directly associated with these wholesome effects. The relevant conclusion within the present research is focused on B. rapa cultivar 163N7 because of its higher gluconapin content and low progoitrin content, which exert anti-cancer and DNA protection properties and could be advised as getting secure and healthier for human consumption. Keywords: turnip greens; gluconapin; progoitrin; overall health; safety; toxicity; chemoprevention1. Introduction Meals, well being and the environmental elements are intimately linked, it becoming necessary to establish a balance among the components of this so called “health trilemma” to get a healthier life on a a lot more sustainable planet. The consumption of plant-based foods with nutraceutical properties is among the crucial things contributing to well-being, and towards the promotion of wellness, to prevent numerous pathologies for example diabetes, cancer and cardiovascular and neurodegenerative ailments [1,2]. Many epidemiological and pharmacological studies have shown that the consumption of a diet rich in cruciferous vegetables (Brassicaceae family) may have a vital role in protection from many chronic illnesses, such as: cardiovascular illness, diabetes (II), dementia, age-related macular degeneration, immune dysfunction, obesity and a few cancers [3]. Plants belonging to various species of Brassica are consumed all over the world, with the most important customers being identified in China, India, Russia, Korea and Japan [6].